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tionality of DNA is an important concept (ie, it always appears on exams) Either of the two strands could be written on top (just rotate the paper by 180 ), but if the DNA codes for a protein, the top strand is usually arranged so that it matches the sequence of the RNA that would be made from the DNA (see later) In Fig 4-2, you re looking at a base pair as it would be seen from above, looking down the helix axis The DNA double helix has two grooves the major and the minor If the helix were flat, the major and minor grooves would correspond to the two different flat surfaces represented by the front and back of the flat sheet The major and minor grooves are different size because the two strands come together so that the angle between corresponding points on the phosphate backbone is not 180 Many of the sequence-specific interactions of proteins with DNA occur along the major groove because the bases (which contain the sequence information) are more exposed along this groove The structures shown in Fig 4-1 are for B-form DNA, the usual form of the molecule in solution Different double-helical DNA structures can be formed by rotating various bonds that connect the structure These are termed different conformations The A and B conformations are both right-handed helices that differ in pitch (how much the helix rises per turn) and other molecular properties Z-DNA is a left-handed helical form of DNA in which the phosphate backbones of the two antiparallel DNA strands are still arranged in a helix but with a more irregular appearance The conformation of DNA (A, B, or Z) depends on the temperature and salt concentration as well as the base composition of the DNA Z-DNA appears to be favored in certain regions of DNA in which the sequence is rich in G and C base pairs.

Figure 4-2

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Normally, SQL statements are executed in a serial fashion A statement comes to the Oracle database and is assigned to a server process to execute A database server has many user processes active at any point in time, and each statement was assigned to a single server process NOTE This description applies to a dedicated server, where there is a one-to-one connection between a user request and a user process on the server Oracle also supports shared servers, where one server process is shared between multiple user requests, but that technology is outside the realm of this chapter Parallel execution is a way to reduce the overall response time of a statement by having multiple processes work on the statement together By dividing the work up among these multiple processes, or parallel servers, each server does less work and finishes that work faster As you will read shortly, there is some overhead involved with this distribution of work, as well as with the re-aggregation of the results of the parallel work, but the overall performance benefit of the parallel operations provides benefits for longer-running operations in most cases

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DNA has a MAJOR AND MINOR GROOVE because the bases attach at an angle that is not 180 apart around the axis of the helix The major groove has more of the bases exposed Sequence-specific interactions with DNA often occur along the major groove Since the helix is right-handed, the next ribose shown is above the last one

Melting is denaturation Annealing is renaturation Hydrophobic stacking provides stability Intercalating agents stack between bases

The Oracle Database can parallelize a range of SQL statements Table 2-1 lists the SQL tasks that can be executed in parallel The tasks listed in Table 2-1 are not all SQL statements The actual implementation of parallelism takes place at the level of the subtasks that make up the overall execution of a statement As an example, the query listed next has four subtasks that can be run in parallel a table scan of each of the two tables, the join operation, and the aggregation requested

Decreased temperature Increased GC content (three hydrogen bonds) Increased salt (ionic strength) The DNA double helix is stabilized by hydrophobic interactions resulting from the individual base pairs stacking on top of each other in the nonpolar interior of the double helix (Figs 4-1 and 4-2) The hydrogen bonds, like the hydrogen bonds of proteins, contribute somewhat to the overall stability of the double helix but contribute greatly to the specificity for forming the correct base pairs An incorrect base pair would not

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