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This is associated with obesity in up to 50% of cases, but the nature of the relationship remains uncertain. Insulin resistance is common and often accompanied by glucose intolerance (including type 2 diabetes in up to 10% of cases) and the characteristic skin lesion, acanthosis nigricans (Figures 13.7 and 21.11). Insulin resistance and hyperinsulinaemia are implicated in the raised androgen levels of PCOS. Panhypopituitarism and growth hormone de ciency are often accompanied by obesity, which may be due to loss of the lipolytic effect of growth hormone. Other features, notably growth arrest in children, may dominate the clinical picture. Hypothalamic lesions, especially those damaging the ventromedial region, can cause severe hyperphagia and obesity. This is probably due to loss of the POMC neurones in the arcuate (tuberoinfundibular) nucleus, which are crucial in mediating the appetite-suppressing action of leptin (see 6). Common causes include tumours (e.g. craniopharyngioma or invasive pituitary macroadenomas), infiltration with tuberculosis or histiocytosis X, or damage following pituitary surgery or radiotherapy. Insulinomas can induce overall hyperphagia and eventual weight gain through hypoglycaemiainduced hunger, possibly enhanced by the anabolic effects of high circulating insulin concentrations.

The method delete(start[,end]) deletes text from the widget. The indexes start and end function as they do for the get method. The method insert(pos,str) inserts the string str just before the index pos:

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124 Multiprotocol Label Switching (MPLS) MPLS has emerged as an important new technology for the Internet It represents the convergence of two fundamentally different approaches in data networking: datagram and virtual circuit Traditionally, each IP packet is forwarded independently by each router hop by hop, based on its destination address, and each router updates its routing table by exchanging routing information with the others On the other hand, ATM and frame relay FR are connection-oriented technologies: a virtual circuit must be set up explicitly by a signaling protocol before packets can be sent into the network MPLS uses a short, fixed-length label inserted into the packet header to forward packets An MPLS-capable router, termed the label-switching router LSR, uses the label in the packet header as an index to find the next hop and the corresponding new label.

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The LSR forwards the packet to its next hop after it replaces the existing label with a new one assigned for the next hop The path that the packet traverses through a MPLS domain is called a label-switched path LSP. Since the mapping between labels is fixed at each LSR, an LSP is determined by the initial label value at the first LSR of the LSP The key idea behind MPLS is the use of a forwarding paradigm based on label swapping that can be combined with a range of different control modules Each control module is responsible for assigning and distributing a set of labels, as well as for maintaining other relevant control information Because MPLS allows different modules to assign labels to packets using a variety of criteria, it decouples the forwarding of a packet from the contents of the packet s IP header.

This property is essential for such features as traffic engineering and virtual private network VPN support Details about MPLS are described in 10..

all resources, including the commons resources, would marginally increase the market cost of products, it could also generate a stream of funding for conservation and environmental management More importantly it would provide the consumer with a valid measure of the true cost of production of the products of interest The practice of ignoring the value of natural resources and environmental assets also extends into the assessment of national economies29 sometimes with very undesirable consequences Valuation suggests a method for converting to monetary value things (such as environmental goods) not typically sold in a marketplace This is an inherently dif cult and to some extent subjective undertaking Environmental accounting is impossible without reliable and good valuation procedures Early attempts at valuation of externalities were primarily via life-cycle analysis (LCA) [22].

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