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20 Baker, R O; Bray, M; Huggins, J W Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections Antiviral Res 2003, 57, 13 23 21 Kern, E R; Hartline, C; Harden, E; Keith, K; Rodriguez, N; Beadle, J R; Hostetler, K Y Enhanced inhibition of orthopoxvirus replication in vitro by alkoxyalkyl esters of cidofovir and cyclic cidofovir Antimicrob Agents Chemother 2002, 46, 991 995 22 Bray, M; Martinez, M; Smee, D F; Kefauver, D; Thompson, E; Huggins, J W Cidofovir protects mice against lethal aerosol or intranasal cowpox virus challenge J Infect Dis 2000, 181, 10 19 23 Bray, M; Martinez, M; Kefauver, D; West, M; Roy, C Treatment of aerosolized cowpox virus infection in mice with aerosolized cidofovir Antiviral Res 2002, 54, 129 142 24 Smee, D F; Bailey, K.

We note, however, that dynamically adjusting nodes location can further increase the dependability of WSNs since the optimality of the initial positions may become void during the operation of the network depending on the network state and various external factors For example, traf c patterns can change based on the monitored events, load may not be balanced among the nodes causing bottlenecks, application-level interest can vary over time, and the available network resources may change due to the depletion of energy of some nodes and/or the addition of more nodes In this chapter we opt to categorize the various strategies for statically positioning base stations and sensor nodes in WSNs We contrast a number of published approaches highlighting their strengths and limitations Our aim is to help applications designers identify alternative solutions and select appropriate strategies.

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You should call this function with preemption disabled since it removes the current thread from the scheduler ready list. The parameters are as follows:

In addition to surveying static positioning approaches, we show that dynamically repositioning nodes while the network is operational can be a very effective means for boosting the network s dependability attributes We describe scenarios for which node relocation can be pursued to counter holes in coverage, achieve/maintain strong network connectivity, preserve sensor s energy, increase data timeliness, and boost the node s physical security We highlight the issues, report on the state of the art, and outline open esearch problem The chapter is organized as follows The next section is dedicated to static strategies for node positioning We separately cover approaches for sensor placement as well as single and multiple base stations positioning In Section 93 we turn our attention to dynamic positioning schemes We highlight the technical issues and describe sample techniques that exploit sensors and base-station repositioning to enhance the network dependability.

W; Wong, M H; Sidwell, R W Intranasal treatment of cowpox virus respiratory infections in mice with cidofovir Antiviral Res 2000, 47, 171 177 25 Smee, D F; Bailey, K W; Sidwell, R W Treatment of lethal vaccinia virus respiratory infections in mice with cidofovir Antiviral Chem Chemother 2001, 12, 71 76 26 Quenelle, D C; Collins, D J; Kern, E R Ef cacy of multiple- or single-dose cidofovir against vaccinia and cowpox virus infections in mice Antimicrob Agents Chemother 2003, 47, 3275 3280 27 Huggins, J W; Martinez, M J; Hartmann, C J; Hensley, L E; Jackson, D L; Refoeven, D F; Kuksh, D A; Lawson, T; Miller, D M; Mucker, E A; Shamblin, J D; Tate, M K; Whitehour, L A; Swiers, S H; Jahrling, P B..

The bulk of the discussion applies to a single base-station setup or to.

aTimeout is the maximum time for which the thread should block, in nanokernel timer ticks; a zero value means wait for ever. If the thread is still blocked when the timeout expires the state handler (which I discuss next) will be called aState is the new N-state corresponding to the wait object. This value will be written into the NThreadBase::iNState eld aWaitObj is a pointer to the new wait object. This value will be written into the NThreadBase::iWaitObj eld. You can use the TPriListLink base class of NThreadBase to attach the thread to a list of threads waiting on the object; note that you must do this after calling the NanoBlock() function. Since preemption is disabled at this point, a reschedule will not occur immediately but will be deferred to the next point at which preemption is re-enabled. Every thread that wants to use a new type of wait object must have a nanokernel state handler installed to handle operations on that thread when it is waiting on the new type of object. A nanokernel state handler is a function with the following signature:

Successful cidofovir treatment of smallpox-like diseases in variola and monkeypox primate models Antiviral Res 2004, 62, A57 28 Cundy, K C; Bidgood, A M; Lynch, G; Shaw, J P; Grif n, L; Lee, W A Pharmacokinetics, bioavailability, metabolism, and tissue distribution of cidofovir (HPMPC) and cyclic HPMPC in rats Drug Metab Dispos 1996, 24, 745 752 29 Cundy, K C; Li, Z H; Hitchcock, M J; Lee, W A Pharmacokinetics of cidofovir in monkeys Evidence for a prolonged elimination phase representing phosphorylated drug Drug Metab Dispos 1996, 24, 738 744 30 Kern, E R In vitro activity of potential anti-poxvirus agents Antiviral Res 2003, 57, 35 40 31 Safrin, S; Cherrington, J; Jaffe, H S Clinical uses of cidofovir Rev Med Virol 1997, 7, 145 156 32 De Clercq, E Cidofovir in the therapy and short-term prophylaxis of poxvirus infections.

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