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Interestingly enough, once the entire network is upgraded to Windows 2000 and switched to native mode, the PDC Emulator still functions to process validation of account lockout requests from other DCs in the domain. In mixed-mode environments where Windows 2000 domain controllers and Windows NT domain controllers coexist, both authentication methods exist and may be used to authenticate either native or down-level clients. Native clients may be authenticated by a BDC using NTLM protocol in the absence of a native domain controller. Other Issues Domain controller infrastructure coexistence is built in and should function seamlessly once implemented. There are other services that carry over from Windows NT that will not function properly; namely, the LAN Manager Replication service and the Remote Access service. See 18 for more information. Security is another major difference between the two operating systems, and beyond the authentication process lie issues of how system policies and trust relationships interoperate amid the two. Windows 2000 uses transitive trusts rather than the explicit trust model used in NT. Careful consideration and planning steps must be taken to ensure the proper installation of trusts between Windows 2000

Game, set, match Maybe. As with other Microsoft online services, you need a Windows Live ID to take advantage of My Phone. After signing onto the service from the Web on your PC, you need to do so as well from your smartphone. Doing so triggers a download for the My Phone application, which sits on your phone and handles the syncing of information between the device and the Internet cloud. On the phone, My Phone is pure simplicity: you can view information about the last sync and manually trigger a new sync if you want. You can select which items you wish to sync via this service (it supports contacts, calendar, tasks, text messages, photos, videos, music, and documents; and, if you have a storage card, additional photos, videos, music, and documents that you might have stored there). And you can configure a default sync schedule. If it works as it should, My Phone will simply work in the background, syncing your data to the My Phone Web site. The rationale here is that people tend to keep important information on their phone, and often only on their phone. And if they lose the phone, or it is stolen, that data is gone for good. With My Phone, it s always backed up, and if you get a different phone in the future because you upgraded or whatever you can get that data off the Web site and onto that new device, too. Viewed from the traditional Web (that is, from a PC), you can see how this works. The My Phone Web site, shown in Figure 19-20, provides a simplified view of the information you ve synced from your phone, as well as quick links to common tasks such as viewing and downloading photos, and managing contacts.

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363 Pharmacogenetics/pharmacogenomics seminars, 96 Pharmacogenetics Research Network, 43, 323 Pharmacogenetics Research Network and Knowledge Base (PharmGKB), 150 Pharmacogenetic tests clinical utility of, 171 175 need for, 175 179 predictive values of, 169 171 regulation of, 179 182 Pharmacogenetic traits, 139 Pharmacogenomic analyses, 125, 155 Pharmacogenomic diagnostics, assessing the use of, 107 108 Pharmacogenomic drugs, under Medicaid, 282 283 Pharmacogenomic in vitro diagnostics, 107 Pharmacogenomic medications, economics of, 332 Pharmacogenomic medicine, 314 public and private uses of race in, 300 306 Pharmacogenomics, ix x, xi, 31 32, 109, 138 141 bene ts of, 230 231 clinical aspects of, x, 151 153, 325 328 commercial aspects of, 110, 123 126 economic implications of, 15 17, 229 250 ef cient uses of, 219 emergence of, 292 ethical, legal, and social implications of, 320 genome era in, 43 45 genotypes and, 199 200 implications of population genetics for, 51 63 importance to pharmaceutics, 211 integration into medical practice, 137 161 intellectual property and commercial aspects of, 109 133 liability issues in, 203, 326 328 macroeconomic effects of, 244 245, 247

Microsoft Exchange uses a graphic administration and monitoring system that integrates with Windows Server 2008 s Microsoft Management Console (MMC) to provide single-seat administration. The MMC does not provide you with management capabilities, but with a common interface that enables you to manage all your needs. The Microsoft Exchange System Manager, Microsoft Active Directory, and Internet Services Manager are snap-ins that provide the management for Server 2008. Policy-based management provides the administrator with the capability to perform single operations made up of hundreds of objects. Policies are a set of objects de ned by the administrator. The administrator can also de ne recipient policies that could potentially affect hundreds of thousands of users, groups, and contacts in Active Directory.

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